Rodu’s research focuses on the substitution of safer tobacco products by smokers who are unable or unwilling to quit smoking with conventional cessation methods because of their addiction to nicotine. His research in comparative epidemiology established the scientific foundation for harm reduction and he continues to study clinical and social interventions aimed at harm reduction.
Latest posts by Brad Rodu (see all)
- The War Against Tobacco Flavors Will Fail - February 7, 2019
- American Cancer Society Sees Zero Cancer Risk for Smokeless Tobacco - June 15, 2018
- UC San Francisco Authors Inadvertently Validate Our Call for Retraction - April 6, 2018
Memorial Sloan Kettering Cancer Center researchers, led by first-author Sarah Borderud, claimed on September 22, 2014, that e-cigarettes did not help cancer patients quit smoking (media story here). They based that statement on a study they published online in Cancer, a journal of the American Cancer Society (abstract here).
The researchers had enrolled 1,074 cancer patients in a smoking cessation program. They subsequently found that “E-cigarette users were as likely to be smoking at the time of follow-up as nonusers (odds ratio, 1.0; 95% confidence interval, 0.5-1.7).”
Upon reading the study, I found a significant error: the main results table reported the exact opposite of the text. On October 16, I submitted a letter to the Cancer editor, co-signed by my colleagues Nantaporn Plurphanswat and Carl Phillips, requesting a correction.
Six weeks later, on November 25, a correction was published on the Cancer website. It said: “The authors discovered some errors…in Table 2.” The circumstances strongly suggest that the authors didn’t “discover” the errors, we did. The journal office had our letter on October 16, six weeks before the correction appeared.
Our letter, published online on March 4 (here), described other problems with the study; one is particularly important. Borderud et al. claimed: “Using an intention-to-treat analysis, E-cigarette users were twice as likely to be smoking at the time of follow-up as nonusers (odds ratio, 2.0; 95% confidence interval, 1.2-3.3).” In other words, e-cigarettes were harmful.
They reached this striking result by assuming that anyone lost during follow-up had continued to smoke. We pointed out that “Smokers who were E-cigarette users were twice as likely to be lost to follow-up as the other smokers (66% vs 32%)… The conclusion that E-cigarette users were twice as likely to be smoking is purely an artifact of the assumption. An equally plausible counter-assumption is that dropouts left the program because they had quit smoking…” They didn’t consider this possibility, but they should have.
Carl Phillips’ goes into more detail about the technical irregularities here.
[Originally published at Tobacco Truth]